CYCLIC AMP IN NORMAL AND MALIGNANT HYPERPYREXIA SUSCEPTIBLE INDIVIDUALS FOLLOWING EXERCISE *
نویسندگان
چکیده
منابع مشابه
Microcalorimetric studies in malignant hyperpyrexia susceptible individuals.
In an attempt to develop a diagnostic test for malignant hyperpyrexia (MH) without the need for open muscle biopsy, we have investigated the change in heat production brought about when platelets and muscle are exposed to halothane and caffeine. Halothane 3% caused platelet aggregation, which was itself associated with heat production. Caffeine 4 mmol litre-1 decreased heat production in platel...
متن کاملCalcium and magnesium contents of malignant hyperpyrexia-susceptible human muscle.
The calcium and magnesium contents of muscle obtained by muscle biopsy of patients referred for malignant hyperpyrexia screening were determined. The susceptibility to malignant hyperpyrexia was made on the basis of the halothane contracture test. No difference in cation concentrations was found between the normal and malignant hyperpyrexia-susceptible groups.
متن کاملProcaine in malignant hyperpyrexia.
The caffeine contracture of normal human muscle, which has been used as a model for malignant hyperpyrexia, is greatly potentiated by halothane. Prior administration of procaine markedly reduces the halothane-potentiated caffeine contracture, and procaine given at the height of the contracture induces relaxation. Lignocaine, on the other hand, produces a variable response and sometimes increase...
متن کاملRhabdomyolysis and malignant hyperpyrexia.
detected in any patient by this method. Fourteen patients had raised serum creatine kinase activity (up to 5000 IU/1, normal range < 170 lU/i) and raised serum aspartate transaminase activity (up to 150 IU/1, normal < 35 IU/1). In all cases enzyme activity fell after admission to hospital. Peak serum creatine kinase activity was not significantly related to weight, sex, level of consciousness, ...
متن کاملDifferential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.
Analysis of cyclic AMP-dependent protein kinase catalytic (C) and regulatory (R) subunits in normal human melanocytes and malignant melanomas demonstrated molar excess of regulatory over catalytic subunit in both cell types. Overall, greater catalytic activity, as a measure of C subunit, and cyclic AMP binding activity, as a measure of R subunit, were detected in metastatic compared to primary ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1984
ISSN: 0007-0912
DOI: 10.1093/bja/56.11.1243